Design, as an advanced system, plays an important role in energy waste in the world. The purpose of this study is to evaluate the effect of an interior green living wall and natural ventilation in the atrium space to reduce energy consumption in a temperate and humid climate. One of the innovative aspects of this research is the focus on the simultaneous analysis of these two variables and showing their synergistic effects on optimizing energy consumption, which in previous studies have been studied independently. The method of this research is descriptive-analytical and simulation. Six building samples in the temperate and humid climate of Mazandaran province were selected, which were first simulated without natural ventilation and green walls on the interior walls of the atrium in the Design Builder software and then examined with them. Simulation results using DesignBuilder software show that the greatest reduction in energy consumption is in building number one in Babol city, which, when using a combined system, has a 54.6 percent reduction in energy consumption in the heating sector and a 24.7 percent reduction in energy consumption in the cooling sector, and carbon dioxide production is also reduced by 31.8 percent. Also, the results of the paired t-test statistical analysis show that the combined system has a significant effect on reducing the total energy consumption of the building and reducing consumption in the cooling sector, but it has no significant effect on heating consumption.