Additive manufacturing or 3D printing is used to make 3D parts. In recent years, many researchers have paid attention to the 3D printing method and this method has been widely used in various fields of engineering such as mechanics, aviation and biopharmaceutical industries. Polyethylene oxide polymer and polyethylene glycol polymer are among the most common polymers in the pharmaceutical and automotive industries and other related industries. In this research, two polymers, polyethylene oxide and polyethylene glycol, were used to fabricate test specimens by the 3D printing method. To investigate the mechanical properties of the manufactured parts under different operating conditions, tensile, hardness and impact tests were used. The obtained results showed that the tensile strength of the specimens decreased with the increase of the layer thickness. In addition, at the same extrusion speed, as the layer thickness increased and the temperature decreased, the hardness of the polymer specimen increased. The results of the impact test also indicated that the higher the hardness and tensile strength, the higher the energy input to the polymer piece. The results also showed that a sample with the highest hardness had higher extrusion speed, medium temperature and layer thickness. With the increase in temperature, a decrease in the hardness of polyethylene glycol polymer was observed when the specimen was constant in speed and layer thickness. The most effective parameter in determining the hardness of polyethylene glycol polymer was temperature.