نوع مقاله : مقاله پژوهشی (کاربردی)
نویسندگان
1 دانشیار، گروه شیمی، دانشگاه حکیم سبزواری، سبزوار، ایران
2 گروه شیمی ، دانشگاه فنی و حرفه ای ، تهران ، ایران
3 دانشجوی ارشد، گروه شیمی، دانشگاه حکیم سبزواری، سبزوار، ایران
چکیده
کلیدواژه‌ها
موضوعات
عنوان مقاله [English]
نویسندگان [English]
Doxorubicin is an anticancer drug that prevents the growth and progression of cancer cells. Considering that in some samples the amount of doxorubicin is very low, so choosing a preconcentrative method is very important and necessary. In this study, dispersive solid phase extraction, by using graphen oxide nano particles, was used as an efficient preconcentration method.Different affecting parameters, such as adsorption time, desorption time, amounts of adsorber, type and volume of organic solvent (desorbing solvent) and pH were investigated and optimized.After optimization of the experimental conditions, doxorubicin concentration was measured at wavelength of 478.5 nm. The calibration curve was linear in the 0.06 to 6.5 mgL-1 doxorubicin concentration range, and the detection limit (at an S/N ratio of 3) was 0.018 mgL⁻¹. Relative standard deviation (RSD%) for ten replicate measurement of doxorubicin solution was 2.8%.The enrichment factor and recovery of the extraction method were 58 and 78% respectively. The proposed method was applied to the determination of doxorubicin in real samples with satisfactory analytical results.
کلیدواژه‌ها [English]
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